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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].

Transporters

940
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B0AT1 / SLC6A19 C Show summary »

B0AT2 / SLC6A15 C Show summary »


Target Id 940
Nomenclature B0AT2
Systematic nomenclature SLC6A15
Previous and unofficial names SBAT1 | solute carrier family 6 (neurotransmitter transporter), member 15 | orphan sodium- and chloride-dependent neurotransmitter transporter NTT73 | orphan transporter v7-3 | solute carrier family 6 (neutral amino acid transporter), member 15 | solute carrier family 6 (neurotransmitter transporter)
Genes SLC6A15 (Hs), Slc6a15 (Mm), Slc6a15 (Rn)
Ensembl ID ENSG00000072041 (Hs), ENSMUSG00000019894 (Mm), ENSRNOG00000027468 (Rn)
UniProtKB AC Q9H2J7 (Hs), Q8BG16 (Mm), Q08469 (Rn)
Bioparadigms SLC Tables SLC6A15 (Hs)
Endogenous substrates L-proline > L-alanine, L-valine, L-methionine, L-leucine > L-isoleucine, L-threonine, L-asparagine, L-serine, L-phenylalanine > glycine  [4]
Selective inhibitors
loratadine pIC50 5.4 [8]
Stoichiometry 1 Na+: 1 amino acid [3]

B0AT3 / SLC6A18 C Show summary »

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

SIT1 / SLC6A20 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.