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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].

Transporters

941
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B0AT1 / SLC6A19 C Show summary »

B0AT2 / SLC6A15 C Show summary »

B0AT3 / SLC6A18 C Show summary »


Target Id 941
Nomenclature B0AT3
Systematic nomenclature SLC6A18
Previous and unofficial names XT2 | XTRP2 | solute carrier family 6 (neurotransmitter transporter), member 18 | b(0)AT3 | renal osmotic stress-induced Na-Cl organic solute cotransporter | Rosit | sodium- and chloride-dependent transporter XTRP2 | X transporter protein 2 | solute carrier family 6 (neutral amino acid transporter), member 18 | solute carrier family 6 (neurotransmitter transporter)
Genes SLC6A18 (Hs), Slc6a18 (Mm), Slc6a18 (Rn)
Ensembl ID ENSG00000164363 (Hs), ENSMUSG00000021612 (Mm), ENSRNOG00000016253 (Rn)
UniProtKB AC Q96N87 (Hs), O88576 (Mm), Q62687 (Rn)
Bioparadigms SLC Tables SLC6A18 (Hs)
Endogenous substrates L-alanine, glycine > L-methionine, L-phenylalanine, L-leucine, L-histidine, L-glutamine  [12]
Stoichiometry Na+- and Cl -dependent transport [11]
Comment SLC6A18 is a functional transporter in mouse, but not in humans.

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

SIT1 / SLC6A20 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.