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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].


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B0AT1 / SLC6A19 C Show summary »

B0AT2 / SLC6A15 C Show summary »

B0AT3 / SLC6A18 C Show summary »

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

Target Id 943
Nomenclature NTT4
Systematic nomenclature SLC6A17
Previous and unofficial names XT1 | XTRP1 | solute carrier family 6 (neurotransmitter transporter), member 17 | orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 | solute carrier family 6 (neutral amino acid transporter), member 17 | solute carrier family 6 (neurotransmitter transporter)
Genes SLC6A17 (Hs), Slc6a17 (Mm), Slc6a17 (Rn)
Ensembl ID ENSG00000197106 (Hs), ENSMUSG00000027894 (Mm), ENSRNOG00000050090 (Rn)
UniProtKB AC Q9H1V8 (Hs), Q8BJI1 (Mm), P31662 (Rn)
Bioparadigms SLC Tables SLC6A17 (Hs)
Endogenous substrates L-leucine, L-methionine, L-proline > L-cysteine, L-alanine, L-glutamine, L-serine > L-histidine, glycine  [14]
Stoichiometry Na+-dependent, Cl--independent transport [14]

SIT1 / SLC6A20 C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.