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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].


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B0AT1 / SLC6A19 C Show summary »

B0AT2 / SLC6A15 C Show summary »

B0AT3 / SLC6A18 C Show summary »

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

SIT1 / SLC6A20 C Show summary »

Target Id 944
Nomenclature SIT1
Systematic nomenclature SLC6A20
Previous and unofficial names IMINO | sodium/imino-acid transporter 1 | XT3 | sodium- and chloride-dependent transporter XTRP3 | solute carrier family 6 (neurotransmitter transporter), member 20 | X transporter protein 3 | Xtrp3s1 | solute carrier family 6 (proline IMINO transporter), member 20 | solute carrier family 6 (neurotransmitter transporter), member 20A | solute carrier family 6 (neurotransmitter transporter) | Slc6a20
Genes SLC6A20 (Hs), Slc6a20a (Mm), Slc6a20a (Rn)
Ensembl ID ENSG00000163817 (Hs), ENSMUSG00000036814 (Mm), ENSRNOG00000006010 (Rn), ENSRNOG00000068642 (Rn)
UniProtKB AC Q9NP91 (Hs), Q8VDB9 (Mm), Q64093 (Rn)
Bioparadigms SLC Tables SLC6A20 (Hs)
Endogenous substrates
Stoichiometry 2 Na+: 1 Cl-: 1 imino acid [2]


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.