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SLC28 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC28 family membersappear to have 13 TM segments with cytoplasmic N-termini and extracellular C-termini, and function as concentrative nucleoside transporters.

Transporters

1114
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CNT1 (Sodium/nucleoside cotransporter 1 / SLC28A1) C Show summary »

Target Id 1114
Nomenclature Sodium/nucleoside cotransporter 1
Systematic nomenclature SLC28A1
Common abbreviation CNT1
Previous and unofficial names concentrative nucleoside transporter 1 | sodium-coupled nucleoside transporter 1 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 | solute carrier family 28 (concentrative nucleoside transporter), member 1 | solute carrier family 28 (sodium-coupled nucleoside transporter)
Genes SLC28A1 (Hs), Slc28a1 (Mm), Slc28a1 (Rn)
Ensembl ID ENSG00000156222 (Hs), ENSMUSG00000025726 (Mm), ENSRNOG00000018940 (Rn)
UniProtKB AC O00337 (Hs), Q62674 (Rn)
Bioparadigms SLC Tables SLC28A1 (Hs)
RESOLUTE SLC28A1 (Hs)
Endogenous substrates
adenosine
uridine
thymidine
cytidine
Substrates
gemcitabine [1]
zidovudine
zalcitabine
ribavirin [2]
Stoichiometry 1 Na+ : 1 nucleoside (in)

CNT2 (Sodium/nucleoside cotransporter 2 / SLC28A2) C Show summary » More detailed page go icon to follow link

CNT3 (Solute carrier family 28 member 3 / SLC28A3) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.