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SLC28 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC28 family membersappear to have 13 TM segments with cytoplasmic N-termini and extracellular C-termini, and function as concentrative nucleoside transporters.

Transporters

1116
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CNT1 (Sodium/nucleoside cotransporter 1 / SLC28A1) C Show summary »

CNT2 (Sodium/nucleoside cotransporter 2 / SLC28A2) C Show summary » More detailed page go icon to follow link

CNT3 (Solute carrier family 28 member 3 / SLC28A3) C Show summary »


Target Id 1116
Nomenclature Solute carrier family 28 member 3
Systematic nomenclature SLC28A3
Common abbreviation CNT3
Previous and unofficial names concentrative nucleoside transporter 3 | concentrative Na(+)-nucleoside cotransporter 3 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 | solute carrier family 28 (concentrative nucleoside transporter), member 3 | solute carrier family 28 (sodium-coupled nucleoside transporter)
Genes SLC28A3 (Hs), Slc28a3 (Mm), Slc28a3 (Rn)
Ensembl ID ENSG00000099118 (Hs), ENSMUSG00000021553 (Mm), ENSRNOG00000018853 (Rn)
UniProtKB AC Q9HAS3 (Hs), Q9ERH8 (Mm), Q8VIH3 (Rn)
Bioparadigms SLC Tables SLC28A3 (Hs)
Endogenous substrates
adenosine
inosine
uridine
guanosine
thymidine
cytidine
Substrates
5-fluorouridine
zebularine
formycin B
gemcitabine
cladribine
floxuridine
zidovudine
zalcitabine
didanosine
Inhibitors
compound 16 [PMID: 19097778] pKi 5.5 [3]
Stoichiometry 2 Na+/H+
Comment CNT3 forms cyclic homotrimers [7]. Genetic variants of SLC28A3 are associated with increased risk of anthracycline-induced cardiomyopathy [6].

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.