Top ▲

SLC30 zinc transporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

Along with the SLC39 family, SLC30 transporters regulate the movement of zinc ions around the cell. In particular, these transporters remove zinc ions from the cytosol, allowing accumulation into intracellular compartments or efflux through the plasma membrane. ZnT1 is thought to be placed on the plasma membrane extruding zinc, while ZnT3 is associated with synaptic vesicles and ZnT4 and ZnT5 are linked with secretory granules. Membrane topology predictions suggest a multimeric assembly, potentially heteromultimeric [4], with subunits having six TM domains, and both termini being cytoplasmic. Dityrosine covalent linking has been suggested as a mechanism for dimerisation, particularly for ZnT3 [3]. The mechanism for zinc transport is unknown.


Click here for help

ZnT1 (Zinc transporter 1 / SLC30A1) Show summary »

Target Id 1121
Nomenclature Zinc transporter 1
Systematic nomenclature SLC30A1
Common abbreviation ZnT1
Previous and unofficial names ZRC1 | solute carrier family 30 (zinc transporter) member 1 | solute carrier family 30 (zinc transporter), member 1 | solute carrier family 30 (zinc transporter)
Genes SLC30A1 (Hs), Slc30a1 (Mm), Slc30a1 (Rn)
Ensembl ID ENSG00000170385 (Hs), ENSMUSG00000037434 (Mm), ENSRNOG00000004749 (Rn)
UniProtKB AC Q9Y6M5 (Hs), Q60738 (Mm), Q62720 (Rn)
Bioparadigms SLC Tables SLC30A1 (Hs)

ZnT2 (Zinc transporter 2 / SLC30A2) Show summary »

ZnT3 (Zinc transporter 3 / SLC30A3) Show summary »

ZnT4 (Zinc transporter 4 / SLC30A4) Show summary »

ZnT5 (Zinc transporter 5 / SLC30A5) Show summary »

ZnT6 (Zinc transporter 6 / SLC30A6) Show summary »

ZnT7 (Zinc transporter 7 / SLC30A7) Show summary »

ZnT8 (Zinc transporter 8 / SLC30A8) Show summary »

ZnT9 (Zinc transporter 9 / SLC30A9) Show summary »

ZnT10 (Zinc transporter 10 / SLC30A10) Show summary »


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

SLC30 zinc transporter family. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.