Top ▲

Free fatty acid receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide More detailed introduction go icon to follow link

Free fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [10,38]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [3,16,19] and FFA4 receptors [12,15,29], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [4,20,27] and FFA3 [4,20] receptors. The crystal structure for agonist bound FFA1 has been described [36].

Receptors

Click here for help

FFA1 receptor C Show summary » More detailed page go icon to follow link

FFA2 receptor C Show summary » More detailed page go icon to follow link

FFA3 receptor C Show summary » More detailed page go icon to follow link

FFA4 receptor C Show summary » More detailed page go icon to follow link

GPR42 Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.