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Amino acid hydroxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The amino acid hydroxylases (monooxygenases), EC.1.14.16.-, are iron-containing enzymes which utilise molecular oxygen and sapropterin as co-substrate and co-factor, respectively. In humans, as well as in other mammals, there are two distinct L-Tryptophan hydroxylase 2 genes. In humans, these genes are located on chromosomes 11 and 12 and encode two different homologous enzymes, TPH1 and TPH2.

Enzymes

1242
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L-Phenylalanine hydroxylase C Show summary » More detailed page go icon to follow link

L-Tyrosine hydroxylase C Show summary » More detailed page go icon to follow link

L-Tryptophan hydroxylase 1 C Show summary »

L-Tryptophan hydroxylase 2 C Show summary »


Target Id 1242
Nomenclature L-Tryptophan hydroxylase 2
Previous and unofficial names Tryptophan 5-monooxygenase 2 | neuronal tryptophan hydroxylase | tryptophan 5-hydroxylase 2 | NTPH
Genes TPH2 (Hs), Tph2 (Mm), Tph2 (Rn)
Ensembl ID ENSG00000139287 (Hs), ENSMUSG00000006764 (Mm), ENSRNOG00000003880 (Rn)
UniProtKB AC Q8IWU9 (Hs), Q8CGV2 (Mm), Q8CGU9 (Rn)
EC number
1.14.16.4
Endogenous activators Protein kinase A-mediated phosphorylation  [7]
Endogenous substrates
L-tryptophan
Products
5-hydroxy-L-tryptophan
Inhibitors
rodatristat pIC50 8.1 [4]
TPT-004 pIC50 7.8 [10]
Selective inhibitors
fenfluramine
α-propyldopacetamide
6-fluorotryptophan [9]
fenclonine

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How to cite this family page

Database page citation:

Amino acid hydroxylases. Accessed on 01/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=249.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.