L-Tyrosine hydroxylase | Amino acid hydroxylases | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

L-Tyrosine hydroxylase

Target not currently curated in GtoImmuPdb

Target id: 1243

Nomenclature: L-Tyrosine hydroxylase

Family: Amino acid hydroxylases, Catecholamine turnover

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 528 11p15.5 TH tyrosine hydroxylase
Mouse - 498 7 88.06 cM Th tyrosine hydroxylase
Rat - 498 1q41 Th tyrosine hydroxylase
Previous and Unofficial Names
Tyrosine 3-monooxygenase | The | tyrosine 3-hydroxylase
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number: L-tyrosine + O2 -> levodopa
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-tyrosine N/A - -
Product Species Reference
levodopa None
Cofactor Species Comments Reference
sapropterin Human
Fe2+ Human
Endogenous activators
Protein kinase A-mediated phosphorylation  [1]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
methyltyrosine Hs Inhibition - -
α-propyldopacetamide Hs Inhibition - -
3-chlorotyrosine Hs Inhibition - -
3-iodotyrosine Hs Inhibition - -
alpha-methyltyrosine Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Segawa syndrome, autosomal recessive
Synonyms: Autosomal recessive dopa-responsive dystonia [Orphanet: ORPHA101150]
OMIM: 605407
Orphanet: ORPHA101150


Show »

1. Joh TH, Park DH, Reis DJ. (1978) Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Proc. Natl. Acad. Sci. U.S.A., 75 (10): 4744-8. [PMID:33381]

How to cite this page

Amino acid hydroxylases: L-Tyrosine hydroxylase . Last modified on 10/07/2018. Accessed on 21/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243.