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Phosphoinositide-specific phospholipase C C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Phosphoinositide-specific phospholipase C (PLC, EC 3.1.4.11), catalyses the hydrolysis of PIP2 to IP3 and 1,2-diacylglycerol, each of which have major second messenger functions. Two domains, X and Y, essential for catalytic activity, are conserved in the different forms of PLC. Isoforms of PLC-β are activated primarily by G protein-coupled receptors through members of the Gq/11 family of G proteins. The receptor-mediated activation of PLC-γ involves their phosphorylation by receptor tyrosine kinases (RTK) in response to activation of a variety of growth factor receptors and immune system receptors. PLC-ε1 may represent a point of convergence of signalling via both G protein-coupled and catalytic receptors. Ca2+ ions are required for catalytic activity of PLC isoforms and have been suggested to be the major physiological form of regulation of PLC-δ activity. PLC has been suggested to be activated non-selectively by the small molecule m3M3FBS [2], although this mechanism of action has been questioned [12]. The aminosteroid U73122 has been described as an inhibitor of phosphoinositide-specific PLC [20], although its selectivity among the isoforms is untested and it has been reported to occupy the H1 histamine receptor [8].

Enzymes

1409
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PLCβ1 C Show summary »

PLCβ2 C Show summary »

PLCβ3 C Show summary »

PLCβ4 C Show summary »

PLCγ1 C Show summary » More detailed page go icon to follow link

PLCγ2 C Show summary » More detailed page go icon to follow link

PLCδ1 C Show summary »


Target Id 1409
Nomenclature PLCδ1
Previous and unofficial names phosphoinositide phospholipase C-delta-1 | phospholipase C delta 1 long form | phospholipase C-III | PLC-delta 1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | PLC-III | phospholipase C
Genes PLCD1 (Hs), Plcd1 (Mm), Plcd1 (Rn)
Ensembl ID ENSG00000187091 (Hs), ENSMUSG00000010660 (Mm), ENSRNOG00000032238 (Rn)
UniProtKB AC P51178 (Hs), Q8R3B1 (Mm), P10688 (Rn)
EC number
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Endogenous activators Transglutaminase II, p122-RhoGAP, spermine, Gβγ  [5,7,15-16]
Endogenous inhibitors Sphingomyelin  [17]

PLCδ3 C Show summary »

PLCδ4 C Show summary »

PLCε1 C Show summary »

PLCζ1 C Show summary »

PLCη1 C Show summary »

PLCη2 C Show summary »

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How to cite this family page

Database page citation:

Phosphoinositide-specific phospholipase C. Accessed on 23/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=274.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.