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Phospholipase A2 C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Phospholipase A2 (PLA2, EC 3.1.1.4) cleaves the sn-2 fatty acid of phospholipids, primarily phosphatidylcholine, to generate lysophosphatidylcholine and arachidonic acid. Most commonly-used inhibitors (e.g. bromoenol lactone, arachidonyl trifluoromethyl ketone or methyl arachidonyl fluorophosphonate) are either non-selective within the family of phospholipase A2 enzymes or have activity against other eicosanoid-metabolising enzymes.

Secreted or extracellular forms: sPLA2-1B, sPLA2-2A, sPLA2-2D, sPLA2-2E, sPLA2-2F, sPLA2-3, sPLA2-10 and sPLA2-12A

Cytosolic, calcium-dependent forms: cPLA2-4A, cPLA2-4B, cPLA2-4C, cPLA2-4D, cPLA2-4E and cPLA2-4F

Other forms: PLA2-G5, iPLA2-G6, PLA2-G7 and PAFAH2 (platelet-activating factor acetylhydrolase 2)

Enzymes

1422
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sPLA2-1B C Show summary » More detailed page go icon to follow link

sPLA2-2A C Show summary » More detailed page go icon to follow link

sPLA2-2D C Show summary »

sPLA2-2E C Show summary »

sPLA2-2F C Show summary »

sPLA2-3 C Show summary »

cPLA2-4A C Show summary » More detailed page go icon to follow link

cPLA2-4B C Show summary »

cPLA2-4C C Show summary »

cPLA2-4D C Show summary »

cPLA2-4E C Show summary »

cPLA2-4F C Show summary »

PLA2-G5 C Show summary »

iPLA2-G6 C Show summary »

PLA2-G7 Show summary » More detailed page go icon to follow link

sPLA2-10 C Show summary »


Target Id 1422
Nomenclature sPLA2-10
Previous and unofficial names GXPLA2 | group 10 secretory phospholipase A2 | group X secretory phospholipase A2 | phosphatidylcholine 2-acylhydrolase 10 | phosphatidylcholine 2-acylhydrolase GX | phospholipase A2 group X | phospholipase A2, group 10 | phospholipase A2, group X | PLA2GX | sPLA2-X | mGXsPLA2 | phospholipase A2
Genes PLA2G10 (Hs), Pla2g10 (Mm), Pla2g10 (Rn)
Ensembl ID ENSG00000069764 (Hs), ENSMUSG00000022683 (Mm), ENSRNOG00000003164 (Rn)
UniProtKB AC O15496 (Hs), Q9QXX3 (Mm), Q9QZT3 (Rn)
EC number
3.1.1.4
Inhibitors
compound 12e [PMID: 18605714] pIC50 7.7 [6]

sPLA2-12A C Show summary »

platelet activating factor acetylhydrolase 2 C Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

Phospholipase A2. Accessed on 23/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=275.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.