Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	749	1q31.1	PLA2G4A	phospholipase A2 group IVA
Mouse	-	748	1 63.51 cM	Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)
Rat	-	752	13q21	Pla2g4a	phospholipase A2 group IVA

Previous and Unofficial Names

Calcium-dependent PLA2 | cytosolic phospholipase A2 α | GIVA | phospholipase A2 group IVA | Pla2c | cPLA2-alpha | cytosolic PLA2 | phospholipase A2, group IVA (cytosolic, calcium-dependent) | phospholipase A2

Database Links
Alphafold	P47712 (Hs), P47713 (Mm), P50393 (Rn)
BRENDA	3.1.1.4
CATH/Gene3D	2.60.40.150
ChEMBL Target	CHEMBL3816 (Hs), CHEMBL2907 (Mm)
DrugBank Target	P47712 (Hs)
Ensembl Gene	ENSG00000116711 (Hs), ENSMUSG00000056220 (Mm), ENSRNOG00000002657 (Rn)
Entrez Gene	5321 (Hs), 18783 (Mm), 24653 (Rn)
Human Protein Atlas	ENSG00000116711 (Hs)
KEGG Enzyme	3.1.1.4
KEGG Gene	hsa:5321 (Hs), mmu:18783 (Mm), rno:24653 (Rn)
Pharos	P47712 (Hs)
UniProtKB	P47712 (Hs), P47713 (Mm), P50393 (Rn)
Wikipedia	PLA2G4A (Hs)

Enzyme Reaction
EC Number: 3.1.1.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 57 [PMID: 16610804] Hs Inhibition 8.4 pIC50 1 ⤷ pIC50 8.4 (IC50 4.3x10-9 M) [1] Description: Inhibition of human isolated cPLA2-4A in a lipid vesicle assay.

Immuno Process Associations

Immuno Process:  Immune regulation

Immuno Process:  Inflammation