Top ▲

Phospholipase A2 C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Phospholipase A2 (PLA2, EC 3.1.1.4) cleaves the sn-2 fatty acid of phospholipids, primarily phosphatidylcholine, to generate lysophosphatidylcholine and arachidonic acid. Most commonly-used inhibitors (e.g. bromoenol lactone, arachidonyl trifluoromethyl ketone or methyl arachidonyl fluorophosphonate) are either non-selective within the family of phospholipase A2 enzymes or have activity against other eicosanoid-metabolising enzymes.

Secreted or extracellular forms: sPLA2-1B, sPLA2-2A, sPLA2-2D, sPLA2-2E, sPLA2-2F, sPLA2-3, sPLA2-10 and sPLA2-12A

Cytosolic, calcium-dependent forms: cPLA2-4A, cPLA2-4B, cPLA2-4C, cPLA2-4D, cPLA2-4E and cPLA2-4F

Other forms: PLA2-G5, iPLA2-G6, PLA2-G7 and PAFAH2 (platelet-activating factor acetylhydrolase 2)

Enzymes

1430
Click here for help

sPLA2-1B C Show summary » More detailed page go icon to follow link

sPLA2-2A Show summary » More detailed page go icon to follow link

sPLA2-2D C Show summary »

sPLA2-2E C Show summary »

sPLA2-2F C Show summary »

sPLA2-3 C Show summary »

cPLA2-4A C Show summary » More detailed page go icon to follow link

cPLA2-4B C Show summary »

cPLA2-4C C Show summary »

cPLA2-4D C Show summary »

cPLA2-4E C Show summary »

cPLA2-4F C Show summary »

PLA2-G5 C Show summary »


Target Id 1430
Nomenclature PLA2-G5
Previous and unofficial names PLA2-10 | calcium-dependent phospholipase A2 | group V phospholipase A2 | phosphatidylcholine 2-acylhydrolase 5 | phospholipase A2 group V | phospholipase A2, group 5 | phospholipase A2
Genes PLA2G5 (Hs), Pla2g5 (Mm), Pla2g5 (Rn)
Ensembl ID ENSG00000127472 (Hs), ENSMUSG00000041193 (Mm), ENSRNOG00000016838 (Rn)
UniProtKB AC P39877 (Hs), P97391 (Mm), P51433 (Rn)
EC number
3.1.1.4
Inhibitors
compound 12e [PMID: 18605714] pIC50 7.5 [6]

iPLA2-G6 C Show summary »

PLA2-G7 Show summary » More detailed page go icon to follow link

sPLA2-10 C Show summary »

sPLA2-12A C Show summary »

platelet activating factor acetylhydrolase 2 C Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Phospholipase A2. Accessed on 01/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=275.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.