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Phospholipase A2 C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Phospholipase A2 (PLA2, EC cleaves the sn-2 fatty acid of phospholipids, primarily phosphatidylcholine, to generate lysophosphatidylcholine and arachidonic acid. Most commonly-used inhibitors (e.g. bromoenol lactone, arachidonyl trifluoromethyl ketone or methyl arachidonyl fluorophosphonate) are either non-selective within the family of phospholipase A2 enzymes or have activity against other eicosanoid-metabolising enzymes.

Secreted or extracellular forms: sPLA2-1B, sPLA2-2A, sPLA2-2D, sPLA2-2E, sPLA2-2F, sPLA2-3, sPLA2-10 and sPLA2-12A

Cytosolic, calcium-dependent forms: cPLA2-4A, cPLA2-4B, cPLA2-4C, cPLA2-4D, cPLA2-4E and cPLA2-4F

Other forms: PLA2-G5, iPLA2-G6, PLA2-G7 and PAFAH2 (platelet-activating factor acetylhydrolase 2)


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sPLA2-1B C Show summary » More detailed page go icon to follow link

sPLA2-2A Show summary » More detailed page go icon to follow link

sPLA2-2D C Show summary »

sPLA2-2E C Show summary »

sPLA2-2F C Show summary »

sPLA2-3 C Show summary »

cPLA2-4A C Show summary » More detailed page go icon to follow link

cPLA2-4B C Show summary »

cPLA2-4C C Show summary »

cPLA2-4D C Show summary »

cPLA2-4E C Show summary »

cPLA2-4F C Show summary »

PLA2-G5 C Show summary »

iPLA2-G6 C Show summary »

Target Id 1431
Nomenclature iPLA2-G6
Previous and unofficial names GVI | PNPLA9 | iPLA2 | 85 kDa calcium-independent phospholipase A2 | caI-PLA2 | group VI phospholipase A2 | GVI PLA2 | phospholipase A2, group VI | iPLA2beta | PARK14 | phospholipase A2, group VI (cytosolic, calcium-independent) | phospholipase A2
Genes PLA2G6 (Hs), Pla2g6 (Mm), Pla2g6 (Rn)
Ensembl ID ENSG00000184381 (Hs), ENSMUSG00000042632 (Mm), ENSRNOG00000012295 (Rn)
UniProtKB AC O60733 (Hs), P97819 (Mm), P97570 (Rn)
EC number

PLA2-G7 Show summary » More detailed page go icon to follow link

sPLA2-10 C Show summary »

sPLA2-12A C Show summary »

platelet activating factor acetylhydrolase 2 C Show summary »


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Further reading

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How to cite this family page

Database page citation:

Phospholipase A2. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.