Top ▲

Inositol monophosphatase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

Inositol monophosphatase (E.C., IMPase, myo-inositol-1(or 4)-phosphate phosphohydrolase) is a magnesium-dependent homodimer which hydrolyses myo-inositol monophosphate to generate myo-inositol and phosphate. Glycerol may be a physiological phosphate acceptor. Li+ is a nonselective un-competitive inhibitor more potent at IMPase 1 (pKi ca. 3.5, [3]; pIC50 3.2, [4]) than IMPase 2 (pIC50 1.8-2.1, [4]). IMPase activity may be inhibited competitively by L690330 (pKi 5.5, [3]), although the enzyme selectivity is not yet established.


Click here for help

IMPase 1 C Show summary » More detailed page go icon to follow link

IMPase 2 C Show summary »


Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

Inositol monophosphatase. Accessed on 12/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.