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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 277 | 8q21.13 | IMPA1 | inositol monophosphatase 1 | |
Mouse | - | 277 | 3 A1 | Impa1 | inositol (myo)-1(or 4)-monophosphatase 1 | |
Rat | - | 277 | 2q23 | Impa1 | inositol monophosphatase 1 |
Previous and Unofficial Names ![]() |
IMP 1 | lithium-sensitive myo-inositol monophosphatase A1 | inositol(myo)-1(or 4)-monophosphatase 1 | Inositol (myo)-1(or 4)-monophosphatase 1 |
Database Links ![]() |
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Alphafold | P29218 (Hs), O55023 (Mm), P97697 (Rn) |
BRENDA | 3.1.3.25 |
ChEMBL Target | CHEMBL1786 (Hs), CHEMBL1293238 (Rn) |
Ensembl Gene | ENSG00000133731 (Hs), ENSMUSG00000027531 (Mm), ENSRNOG00000010482 (Rn) |
Entrez Gene | 3612 (Hs), 55980 (Mm), 83523 (Rn) |
Human Protein Atlas | ENSG00000133731 (Hs) |
KEGG Enzyme | 3.1.3.25 |
KEGG Gene | hsa:3612 (Hs), mmu:55980 (Mm), rno:83523 (Rn) |
OMIM | 602064 (Hs) |
Pharos | P29218 (Hs) |
UniProtKB | P29218 (Hs), O55023 (Mm), P97697 (Rn) |
Wikipedia | IMPA1 (Hs) |
Enzyme Reaction ![]() |
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Rank order of affinity (Human) |
inositol 4-phosphate > inositol 3-phosphate > inositol 1-phosphate [1] |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
Lithium is administered as salts such as lithium carbonate and lithium nitrate. |
Inositol monophosphatase: IMPase 1. Last modified on 26/03/2014. Accessed on 07/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1463.