Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	277	8q21.13	IMPA1	inositol monophosphatase 1
Mouse	-	277	3 A1	Impa1	inositol (myo)-1(or 4)-monophosphatase 1
Rat	-	277	2q23	Impa1	inositol monophosphatase 1

Previous and Unofficial Names

IMP 1 | lithium-sensitive myo-inositol monophosphatase A1 | inositol(myo)-1(or 4)-monophosphatase 1 | Inositol (myo)-1(or 4)-monophosphatase 1

Database Links
Alphafold	P29218 (Hs), O55023 (Mm), P97697 (Rn)
BRENDA	3.1.3.25
ChEMBL Target	CHEMBL1786 (Hs), CHEMBL1293238 (Rn)
Ensembl Gene	ENSG00000133731 (Hs), ENSMUSG00000027531 (Mm), ENSRNOG00000010482 (Rn)
Entrez Gene	3612 (Hs), 55980 (Mm), 83523 (Rn)
Human Protein Atlas	ENSG00000133731 (Hs)
KEGG Enzyme	3.1.3.25
KEGG Gene	hsa:3612 (Hs), mmu:55980 (Mm), rno:83523 (Rn)
OMIM	602064 (Hs)
Pharos	P29218 (Hs)
UniProtKB	P29218 (Hs), O55023 (Mm), P97697 (Rn)
Wikipedia	IMPA1 (Hs)

Enzyme Reaction
EC Number: 3.1.3.25

Rank order of affinity (Human)

inositol 4-phosphate > inositol 3-phosphate > inositol 1-phosphate  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference Li+ Hs Inhibition 3.5 pKi 1 ⤷ pKi 3.5 [1]
Inhibitor Comments
Lithium is administered as salts such as lithium carbonate and lithium nitrate.