Top ▲

IMPase 1

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1463

Nomenclature: IMPase 1

Family: Inositol monophosphatase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 277 8q21.13 IMPA1 inositol monophosphatase 1
Mouse - 277 3 A1 Impa1 inositol (myo)-1(or 4)-monophosphatase 1
Rat - 277 2q23 Impa1 inositol monophosphatase 1
Previous and Unofficial Names Click here for help
IMP 1 | lithium-sensitive myo-inositol monophosphatase A1 | inositol(myo)-1(or 4)-monophosphatase 1 | Inositol (myo)-1(or 4)-monophosphatase 1
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:
Rank order of affinity (Human)
inositol 4-phosphate > inositol 3-phosphate > inositol 1-phosphate  [1]

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Li+ Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 3.5 pKi 1
pKi 3.5 [1]
Inhibitor Comments
Lithium is administered as salts such as lithium carbonate and lithium nitrate.


Show »

1. McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI. (1992) cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. Biochem J, 284 ( Pt 3): 749-54. [PMID:1377913]

How to cite this page

Inositol monophosphatase: IMPase 1. Last modified on 26/03/2014. Accessed on 01/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY,