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Protein kinase C (PKC) family C


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Protein kinase C is the target for the tumour-promoting phorbol esters, such as tetradecanoyl-β-phorbol acetate (TPA, also known as phorbol 12-myristate 13-acetate).

Classical protein kinase C isoforms: PKCα, PKCβ, and PKCγ are activated by Ca2+ and diacylglycerol, and may be inhibited by GF109203X, calphostin C, Gö 6983, chelerythrine and Ro31-8220.

Novel protein kinase C isoforms: PKCδ, PKCε, PKCη, PKCθ and PKCμ are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.

Atypical protein kinase C isoforms:PKCι, PKCζ.


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How to cite this family page

Database page citation:

Protein kinase C (PKC) family. Accessed on 11/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.