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Adenosine receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [23]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [14,34,56,64], agonist-bound [51-52,77] and G protein-bound A2A adenosine receptors [12] have been described. The structures of an antagonist-bound A1 receptor [27] and an adenosine-bound A1 receptor-Gi complex [19] have been resolved by cryo-electronmicroscopy. Another structure of an antagonist-bound A1 receptor obtained with X-ray crystallography has also been reported [13].


A1 receptor C Show summary » More detailed page

A2A receptor C Show summary » More detailed page

A2B receptor C Show summary » More detailed page

A3 receptor C Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adriaan P. IJzerman, Bertil B. Fredholm, Bruno G. Frenguelli, Rebecca Hills, Kenneth A. Jacobson, Karl-Norbert Klotz, Joel Linden, Christa E. Müller, Ulrich Schwabe, Gary L. Stiles. Adenosine receptors. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.