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Receptor tyrosine phosphatase (RTP) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Receptor tyrosine phosphatases (RTP) are cell-surface proteins with a single TM region and intracellular phosphotyrosine phosphatase activity. Many family members exhibit constitutive activity in heterologous expression, dephosphorylating intracellular targets such as Src tyrosine kinase (SRC) to activate signalling cascades. Family members bind components of the extracellular matrix or cell-surface proteins indicating a role in intercellular communication.

Receptors

1862
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RTP Type A C Show summary »

RTP Type B C Show summary » More detailed page go icon to follow link

RTP Type C C Show summary » More detailed page go icon to follow link

RTP Type D C Show summary » More detailed page go icon to follow link

RTP Type E C Show summary »

RTP Type F C Show summary » More detailed page go icon to follow link

RTP Type G C Show summary »

RTP Type H C Show summary »

RTP Type J C Show summary »

RTP Type K C Show summary »

RTP Type M C Show summary »

RTP Type N C Show summary »

RTP Type N2 C Show summary »


Target Id 1862
Nomenclature RTP Type N2
Previous and unofficial names ICAAR | Islet cell antigen 2β | phogrin | protein tyrosine phosphatase, receptor type, N polypeptide 2 | IA-2beta | protein tyrosine phosphatase, receptor type N2 | protein tyrosine phosphatase
Genes PTPRN2 (Hs), Ptprn2 (Mm), Ptprn2 (Rn)
Ensembl ID ENSG00000155093 (Hs), ENSMUSG00000056553 (Mm), ENSRNOG00000005003 (Rn)
UniProtKB AC Q92932 (Hs), P80560 (Mm), Q63475 (Rn)

RTP Type O C Show summary »

RTP Type Q C Show summary »

RTP Type R C Show summary »

RTP Type S C Show summary »

RTP Type T C Show summary »

RTP Type U C Show summary »

RTP Type Z1 C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

Receptor tyrosine phosphatase (RTP) family. Accessed on 20/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=333.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.