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RTP Type C

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1852

Nomenclature: RTP Type C

Family: Receptor tyrosine phosphatase (RTP) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1306 1q31.3-q32.1 PTPRC protein tyrosine phosphatase receptor type C
Mouse 1 1293 1 60.73 cM Ptprc protein tyrosine phosphatase, receptor type, C
Rat 1 1273 13q13 Ptprc protein tyrosine phosphatase, receptor type, C
Previous and Unofficial Names Click here for help
RT7 | protein tyrosine phosphatase, receptor type, C | T200 glycoprotein | CD45 | gp180 | LCA | Ly-5 | Lyt-4 | T200 leukocyte common antigen | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type C
Database Links Click here for help
Alphafold P08575 (Hs), P06800 (Mm), P04157 (Rn)
CATH/Gene3D 2.60.40.10, 3.90.190.10
ChEMBL Target CHEMBL3243 (Hs)
Ensembl Gene ENSG00000081237 (Hs), ENSMUSG00000026395 (Mm), ENSRNOG00000000655 (Rn)
Entrez Gene 5788 (Hs), 19264 (Mm), 24699 (Rn)
Human Protein Atlas ENSG00000081237 (Hs)
KEGG Gene hsa:5788 (Hs), mmu:19264 (Mm), rno:24699 (Rn)
OMIM 151460 (Hs)
Pharos P08575 (Hs)
UniProtKB P08575 (Hs), P06800 (Mm), P04157 (Rn)
Wikipedia PTPRC (Hs)
Natural/Endogenous Ligands Click here for help
galectin-1 {Sp: Human}
Comments: Putative endogenous ligand.
Immunopharmacology Comments
CD45 is a high molecular weight cell surface glycoprotein expressed by cells of hematopoietic origin. Alternate transcripts lead to expression of isoforms that differ in their extracellular (ligand binding) domain (potentially facilitating differential and/or cell type specific biological functions [1]) but all contain the same intracellular domain that has tyrosine phosphatase activity. In relation to immune pathology, a single report from 1992 notes the presence of autoantibodies to CD45 in serum from patients with active systemic lupus erythematosus [2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0050764 regulation of phagocytosis IDA
GO:1903979 negative regulation of microglial cell activation TAS
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
click arrow to show/hide IEA associations
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 14 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030217 T cell differentiation ISS
GO:0042102 positive regulation of T cell proliferation ISS
GO:0042110 T cell activation TAS
GO:1904155 DN2 thymocyte differentiation TAS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0042492 gamma-delta T cell differentiation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046633 alpha-beta T cell proliferation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 7 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030183 B cell differentiation ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 14 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0002639 positive regulation of immunoglobulin production IMP
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042102 positive regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS
GO:1903979 negative regulation of microglial cell activation TAS
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 10 GO processes
GO:0001779 natural killer cell differentiation ISS
GO:0030183 B cell differentiation ISS
GO:0030217 T cell differentiation ISS
GO:0048539 bone marrow development IMP
GO:1904155 DN2 thymocyte differentiation TAS
click arrow to show/hide IEA associations
GO:0042492 gamma-delta T cell differentiation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS
GO:0032677 regulation of interleukin-8 production IDA
GO:0032703 negative regulation of interleukin-2 production ISS
GO:0032743 positive regulation of interleukin-2 production ISS
GO:0032760 positive regulation of tumor necrosis factor production ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 4 GO processes
GO:0042102 positive regulation of T cell proliferation ISS
click arrow to show/hide IEA associations
GO:0007159 leukocyte cell-cell adhesion IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 20 GO processes
GO:0001779 natural killer cell differentiation ISS
GO:0030183 B cell differentiation ISS
GO:0030217 T cell differentiation ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
GO:0042102 positive regulation of T cell proliferation ISS
GO:0042110 T cell activation TAS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS
GO:1903979 negative regulation of microglial cell activation TAS
GO:1904155 DN2 thymocyte differentiation TAS
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
click arrow to show/hide IEA associations
GO:0042492 gamma-delta T cell differentiation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046633 alpha-beta T cell proliferation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

References

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1. Dalchau R, Fabre JW. (1981) Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule. J Exp Med, 153 (4): 753-65. [PMID:6166706]

2. Winfield JB, Mimura T, Fernsten PD. (1992) Autoantibodies to CD45 in systemic lupus erythematosus. Int J Clin Lab Res, 21 (4): 292-5. [PMID:1534265]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type C. Last modified on 19/04/2017. Accessed on 05/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1852.