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AMPK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Activators that are selective for human AMPKβ2-containing heterotrimers that are expressed in skeletal muscle and liver, are being examined as a novel option to treat metabolic disorders including NASH and diabetes [3,6].

Enzymes

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AMPK (AMP kinase) Show summary » More detailed page go icon to follow link

AMPKA1 (protein kinase AMP-activated catalytic subunit alpha 1) Show summary » More detailed page go icon to follow link

AMPKA2 (protein kinase AMP-activated catalytic subunit alpha 2) Show summary » More detailed page go icon to follow link

AMPKB1 (protein kinase AMP-activated non-catalytic subunit beta 1) Show summary » More detailed page go icon to follow link

AMPKB2 (protein kinase AMP-activated non-catalytic subunit beta 2) Show summary » More detailed page go icon to follow link

AMPKG1 (protein kinase AMP-activated non-catalytic subunit gamma 1) Show summary » More detailed page go icon to follow link

AMPKG2 (protein kinase AMP-activated non-catalytic subunit gamma 2) Show summary » More detailed page go icon to follow link

AMPKG3 (protein kinase AMP-activated non-catalytic subunit gamma 3) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

AMPK subfamily. Accessed on 17/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=474.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.