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protein kinase AMP-activated non-catalytic subunit beta 2

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Target not currently curated in GtoImmuPdb

Target id: 1544

Nomenclature: protein kinase AMP-activated non-catalytic subunit beta 2

Abbreviated Name: AMPKB2

Family: AMPK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 272 1q21.1 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2
Mouse - 36 3 F2.2 Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
Rat - 179 2q34 Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2
Previous and Unofficial Names Click here for help
AMP-activated protein kinase beta-2 regulatory subunit | AMPK subunit beta-2 | protein kinase
Database Links Click here for help
Alphafold O43741 (Hs), Q7TQI6 (Mm), Q6AYZ8 (Rn)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL2117 (Hs)
Ensembl Gene ENSG00000131791 (Hs), ENSMUSG00000038205 (Mm), ENSRNOG00000018166 (Rn)
Entrez Gene 5565 (Hs), 108097 (Mm), 64562 (Rn)
Human Protein Atlas ENSG00000131791 (Hs)
KEGG Gene hsa:5565 (Hs), mmu:108097 (Mm), rno:64562 (Rn)
OMIM 602741 (Hs)
Pharos O43741 (Hs)
RefSeq Nucleotide NM_005399 (Hs), NM_182997 (Mm), NM_022627 (Rn)
RefSeq Protein NP_005390 (Hs), NP_892042 (Mm), NP_072149 (Rn)
UniProtKB O43741 (Hs), Q7TQI6 (Mm), Q6AYZ8 (Rn)
Wikipedia PRKAB2 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MT47-100 Small molecule or natural product Click here for species-specific activity table Hs Negative 4.6 pKi 1
⤷ pKi 4.6 (Ki 2.48x10-5 M) [1]

References

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1. Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE et al.. (2015) Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Chem Biol, 22 (6): 705-11. [PMID:26091167]

How to cite this page

AMPK subfamily: protein kinase AMP-activated non-catalytic subunit beta 2. Last modified on 30/03/2016. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1544.