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GSK subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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GSK3A and GSK3B are protein Ser/Thr kinases that are involved in the regulation of glycogen synthesis. GSK3B (GSK-3β) has been associated with the pathogenesis and progression of diseases including obesity, diabetes, cancer and Alzheimer's, and as a result pharmacological inhibition of this enzyme is an attractive therapeutic mechanism.


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GSK3A (glycogen synthase kinase 3 alpha) Show summary » More detailed page go icon to follow link

GSK3B (glycogen synthase kinase 3 beta) C Show summary » More detailed page go icon to follow link

Further reading

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How to cite this family page

Database page citation:

GSK subfamily. Accessed on 21/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.