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Janus kinase (JakA) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). They are essential for cytokine signalling and are strongly linked to both cancer and inflammatory diseases.

Enzymes

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JAK1 (Janus kinase 1) C Show summary » More detailed page go icon to follow link

JAK2 (Janus kinase 2) C Show summary » More detailed page go icon to follow link

JAK3 (Janus kinase 3) C Show summary » More detailed page go icon to follow link

Tyk2 (tyrosine kinase 2) C Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Janus kinase (JakA) family. Accessed on 29/06/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=581.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.