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1.-.-.- Oxidoreductases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3222
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aldehyde dehydrogenase 2 family member Show summary » More detailed page go icon to follow link

aldo-keto reductase family 1 member B Show summary » More detailed page go icon to follow link

VAP-1 (amine oxidase copper containing 3) Show summary » More detailed page go icon to follow link

catalase C Show summary » More detailed page go icon to follow link

DHFR (dihydrofolate reductase) C Show summary » More detailed page go icon to follow link

DHODH (dihydroorotate dehydrogenase (quinone)) C Show summary » More detailed page go icon to follow link

glutathione-disulfide reductase Show summary » More detailed page go icon to follow link

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Show summary » More detailed page go icon to follow link

4-hydroxyphenylpyruvate dioxygenase Show summary » More detailed page go icon to follow link

11-βHSD1 (hydroxysteroid 11-beta dehydrogenase 1) Show summary » More detailed page go icon to follow link

11-βHSD2 (hydroxysteroid 11-beta dehydrogenase 2) Show summary » More detailed page go icon to follow link

hydroxysteroid 17-beta dehydrogenase 2 Show summary » More detailed page go icon to follow link

hydroxysteroid 17-beta dehydrogenase 13 Show summary »


Target Id 3222
Nomenclature hydroxysteroid 17-beta dehydrogenase 13
Genes HSD17B13 (Hs), Hsd17b13 (Mm), Hsd17b13 (Rn)
Ensembl ID ENSG00000170509 (Hs), ENSMUSG00000034528 (Mm), ENSRNOG00000002212 (Rn)
UniProtKB AC Q7Z5P4 (Hs), Q8VCR2 (Mm), Q5M875 (Rn)
Inhibitors
BI-3231 [17]
Comment HSD17B13 is a novel drug target for nonalcoholic steatohepatitis (NASH) and other liver diseases. Estradiol and leukotriene B4 (LTB4) are potential HSD17B13 substrates [17].

IMPDH1 (inosine monophosphate dehydrogenase 1) C Show summary » More detailed page go icon to follow link

IMPDH2 (inosine monophosphate dehydrogenase 2) C Show summary » More detailed page go icon to follow link

myeloperoxidase Show summary » More detailed page go icon to follow link

sepiapterin reductase Show summary » More detailed page go icon to follow link

steroid 5 alpha-reductase 2 Show summary » More detailed page go icon to follow link

tyrosinase Show summary » More detailed page go icon to follow link

vitamin K epoxide reductase complex subunit 1 Show summary » More detailed page go icon to follow link

XDH (xanthine dehydrogenase) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

1.-.-.- Oxidoreductases. Accessed on 25/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=840.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.