glutathione-disulfide reductase | 1.-.-.- Oxidoreductases | IUPHAR/BPS Guide to PHARMACOLOGY

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glutathione-disulfide reductase

Target not currently curated in GtoImmuPdb

Target id: 2613

Nomenclature: glutathione-disulfide reductase

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 522 8p21.1 GSR glutathione-disulfide reductase
Mouse - 500 8 A4 Gsr glutathione reductase
Rat - 424 16q12.3 Gsr glutathione-disulfide reductase
Previous and Unofficial Names
glutathione reductase, mitochondrial | glutathione reductase
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5
PDB Id:  2GH5
Resolution:  1.7Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Catalytic cycle of human glutathione reductase near 1 A resolution
Resolution:  1.8Å
Species:  Human
References:  2
Enzyme Reaction
EC Number:

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Ligand Sp. Action Value Parameter Reference
carmustine N/A Inhibition 4.2 pIC50 3
pIC50 4.2 (IC50 7.1x10-5 M) [3]
Description: The enzyme inhibition assay uses purified S. cerevisiae glutathione reductase
oxiglutatione Hs Inhibition - -
View species-specific inhibitor tables
Inhibitor Comments
Apart from the CHEMBL listing of oxiglutatione as an approved drug acting at glutathione reductase and one PubMed reference describing a its use in a single clinical case study [4], there is very little information available about this drug and its mechanism of action.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hemolytic anemia due to glutathione reductase deficiency
Orphanet: ORPHA90030


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1. Bauer H, Fritz-Wolf K, Winzer A, Kühner S, Little S, Yardley V, Vezin H, Palfey B, Schirmer RH, Davioud-Charvet E. (2006) A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. J. Am. Chem. Soc., 128 (33): 10784-94. [PMID:16910673]

2. Berkholz DS, Faber HR, Savvides SN, Karplus PA. (2008) Catalytic cycle of human glutathione reductase near 1 A resolution. J. Mol. Biol., 382 (2): 371-84. [PMID:18638483]

3. Liu X, Sturla SJ. (2009) Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues. Mol Biosyst, 5 (9): 1013-24. [PMID:19668867]

4. Nakatani Y, Nishimura A, Sugiyama K. (2013) Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy. J Ophthalmic Inflamm Infect, 3 (1): 18. [PMID:23514564]

How to cite this page

1.-.-.- Oxidoreductases: glutathione-disulfide reductase. Last modified on 13/08/2015. Accessed on 04/06/2020. IUPHAR/BPS Guide to PHARMACOLOGY,