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2.3.1.- Acyltransferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3211
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fatty acid synthase Show summary » More detailed page go icon to follow link

diacylglycerol O-acyltransferase 1 Show summary » More detailed page go icon to follow link

diacylglycerol O-acyltransferase 2 Show summary »


Target Id 3211
Nomenclature diacylglycerol O-acyltransferase 2
Genes DGAT2 (Hs), Dgat2 (Mm), Dgat2 (Rn)
Ensembl ID ENSG00000062282 (Hs), ENSMUSG00000030747 (Mm), ENSRNOG00000016573 (Rn)
UniProtKB AC Q96PD7 (Hs), Q9DCV3 (Mm), Q5FVP8 (Rn)
EC number
2.3.1.20
2.3.1.76
Inhibitors
PF-07202954 pIC50 8.0 [2]
ervogastat pIC50 7.8 [3]
ervogastat pIC50 6.1 [3] - Rat
Comment DGAT2 is a therapeutic target for the treatment of non-alcoholic steatohepatitis. Inhibitors like ervogastat are predicted to reduce accumulation of fibrosis-inducing triglycerides in the liver.

monoacylglycerol O-acyltransferase 2 C Show summary » More detailed page go icon to follow link

N-acetyltransferase 8 like Show summary » More detailed page go icon to follow link

zinc finger DHHC-type palmitoyltransferase 3 Show summary »

zinc finger DHHC-type palmitoyltransferase 6 Show summary »

References

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How to cite this family page

Database page citation:

2.3.1.- Acyltransferases. Accessed on 23/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=844.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.