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2.1.1.43 Histone methyltransferases (HMTs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

2702
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ASH1 like histone lysine methyltransferase Show summary »

DOT1 like histone lysine methyltransferase Show summary » More detailed page go icon to follow link

euchromatic histone lysine methyltransferase 1 Show summary »

euchromatic histone lysine methyltransferase 2 Show summary »

EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) Show summary » More detailed page go icon to follow link

EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Show summary » More detailed page go icon to follow link

lysine methyltransferase 2B Show summary »

lysine methyltransferase 2A Show summary »

lysine methyltransferase 2C Show summary »

lysine methyltransferase 2D Show summary »

lysine methyltransferase 2E (inactive) Show summary »

lysine methyltransferase 5A Show summary »

lysine methyltransferase 5B Show summary »

lysine methyltransferase 5C Show summary »

nuclear receptor binding SET domain protein 1 Show summary »

PR/SET domain 2 Show summary »

SET domain containing 1A, histone lysine methyltransferase Show summary »

SET domain containing 1B, histone lysine methyltransferase Show summary »

SET domain containing 2, histone lysine methyltransferase Show summary »


Target Id 2702
Nomenclature SET domain containing 2, histone lysine methyltransferase
Previous and unofficial names KMT3A | SET2 | SET domain containing 2
Genes SETD2 (Hs), Setd2 (Mm), Setd2 (Rn)
Ensembl ID ENSG00000181555 (Hs), ENSMUSG00000044791 (Mm), ENSRNOG00000020915 (Rn)
UniProtKB AC Q9BYW2 (Hs), E9Q5F9 (Mm)
EC number
2.1.1.43
Comment SETD2 has been identified as a druggable target that lies downstream of a cancer-causing mutation in the NSD2 (MMSET) gene that is found in a proportion of multiple myelomas [25]. Epizyme have designed EPZ-719 to target SETD2. In preclinical studies EPZ-719 induces tumour growth inhibition in mice with myeloma tumours with and without the NSD2 mutation.

SET domain containing 7, histone lysine methyltransferase Show summary » More detailed page go icon to follow link

SET domain bifurcated histone lysine methyltransferase 1 Show summary »

SET domain bifurcated histone lysine methyltransferase 2 Show summary »

SET and MYND domain containing 2 Show summary » More detailed page go icon to follow link

SUV39H1 histone lysine methyltransferase Show summary »

SUV39H2 histone lysine methyltransferase Show summary »

References

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How to cite this family page

Database page citation:

2.1.1.43 Histone methyltransferases (HMTs). Accessed on 17/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=871.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.