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2.1.1.43 Histone methyltransferases (HMTs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3220
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ASH1 like histone lysine methyltransferase Show summary »

DOT1 like histone lysine methyltransferase Show summary » More detailed page go icon to follow link

euchromatic histone lysine methyltransferase 1 Show summary »

euchromatic histone lysine methyltransferase 2 Show summary »

EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) Show summary » More detailed page go icon to follow link

EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Show summary » More detailed page go icon to follow link

lysine methyltransferase 2B Show summary »

lysine methyltransferase 2A Show summary »

lysine methyltransferase 2C Show summary »

lysine methyltransferase 2D Show summary »

lysine methyltransferase 2E (inactive) Show summary »

lysine methyltransferase 5A Show summary »

lysine methyltransferase 5B Show summary »

lysine methyltransferase 5C Show summary »

nuclear receptor binding SET domain protein 1 Show summary »

nuclear receptor binding SET domain protein 2 Show summary »


Target Id 3220
Nomenclature nuclear receptor binding SET domain protein 2
Previous and unofficial names KMT3G | MMSET | multiple myeloma SET domain containing protein
Genes NSD2 (Hs), Nsd2 (Mm), Nsd2 (Rn)
Ensembl ID ENSG00000109685 (Hs), ENSMUSG00000057406 (Mm), ENSRNOG00000038140 (Rn)
UniProtKB AC O96028 (Hs), Q8BVE8 (Mm)
EC number
2.1.1.357
Inhibitors
compound 15a [PMID: 36642961] pIC50 6.6 [35]
Comment NSD2 is a histone lysine methyltransferase enzyme. Its primary role is H3K36 dimethylation. Aberrant expression or function of NSD2 has been detected in hematological malignancies and solid tumours. It has therefore been proposed as a tractable oncology therapeutic target.

PR/SET domain 2 Show summary »

SET domain containing 1A, histone lysine methyltransferase Show summary »

SET domain containing 1B, histone lysine methyltransferase Show summary »

SET domain containing 2, histone lysine methyltransferase Show summary »

SET domain containing 7, histone lysine methyltransferase Show summary » More detailed page go icon to follow link

SET domain bifurcated histone lysine methyltransferase 1 Show summary »

SET domain bifurcated histone lysine methyltransferase 2 Show summary »

SET and MYND domain containing 2 Show summary » More detailed page go icon to follow link

SUV39H1 histone lysine methyltransferase Show summary »

SUV39H2 histone lysine methyltransferase Show summary »

References

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How to cite this family page

Database page citation:

2.1.1.43 Histone methyltransferases (HMTs). Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=871.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.