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Kelch-like proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Keap1 is involved in the Keap1-Nrf2-ARE signaling pathway that is essential for protecting cells from oxidative stress. Nrf2 = nuclear factor erythroid 2-related factor 2; ARE = antioxidant response elements.

Targets

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kelch like ECH-associated protein 1 Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Kelch-like proteins. Accessed on 25/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=876.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.