Kelch-like proteins
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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More detailed introduction 
Keap1 is involved in the Keap1-Nrf2-ARE signaling pathway that is essential for protecting cells from oxidative stress. Nrf2 = nuclear factor erythroid 2-related factor 2; ARE = antioxidant response elements.
Targets
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kelch like ECH-associated protein 1
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How to cite this family page
Database page citation:
Kelch-like proteins. Accessed on 03/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=876.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.
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