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Notch receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Aberrant Notch signalling is implicated in a number of human cancers [7,12,14,17], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [3,10].

Targets

2862
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notch receptor 1 C Show summary » More detailed page go icon to follow link

notch receptor 2 C Show summary » More detailed page go icon to follow link

notch receptor 3 C Show summary » More detailed page go icon to follow link

notch receptor 4 C Show summary »


Target Id 2862
Nomenclature notch receptor 4
Previous and unofficial names INT3 | Notch homolog 4 (Drosophila) | notch 4
Genes NOTCH4 (Hs), Notch4 (Mm), Notch4 (Rn)
Ensembl ID ENSG00000204301 (Hs), ENSMUSG00000015468 (Mm), ENSRNOG00000000442 (Rn)
UniProtKB AC Q99466 (Hs), P31695 (Mm)
Comment Notch receptor 4 is a potential therapeutic molecular target for triple-negative breast cancer [8,11].

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.