Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	2471	1p12	NOTCH2	notch receptor 2
Mouse	1	2473	3 42.42 cM	Notch2	notch 2
Rat	1	2471	2q34	Notch2	notch receptor 2

Previous and Unofficial Names

notch 2 | "Notch homolog 2 (Drosophila)

Database Links
Alphafold	Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
CATH/Gene3D	1.25.40.20
ChEMBL Target	CHEMBL3407320 (Hs)
Ensembl Gene	ENSG00000134250 (Hs), ENSMUSG00000027878 (Mm), ENSRNOG00000018835 (Rn)
Entrez Gene	4853 (Hs), 18129 (Mm), 29492 (Rn)
Human Protein Atlas	ENSG00000134250 (Hs)
KEGG Gene	hsa:4853 (Hs), mmu:18129 (Mm), rno:29492 (Rn)
OMIM	600275 (Hs)
Pharos	Q04721 (Hs)
RefSeq Nucleotide	NM_024408 (Hs), NM_010928 (Mm), NM_024358 (Rn)
RefSeq Protein	NP_077719 (Hs), NP_035058 (Mm), NP_077334 (Rn)
UniProtKB	Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
Wikipedia	NOTCH2 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference tarextumab Hs Binding >10.0 pKd 1 ⤷ pKd >10.0 (Kd <1x10-10 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0002437 inflammatory response to antigenic stimulus IEA GO:0043011 myeloid dendritic cell differentiation IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002315 marginal zone B cell differentiation ISS

Immuno Process:  Immune system development GO Annotations:  Associated to 3 GO processes GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0043011 myeloid dendritic cell differentiation IEA GO:0045672 positive regulation of osteoclast differentiation IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:2001204 regulation of osteoclast development IMP click arrow to show/hide IEA associations GO:0045672 positive regulation of osteoclast differentiation IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0043011 myeloid dendritic cell differentiation IEA

Immuno Process:  Cytokine production & signalling

Immuno Process:  Tissue repair GO Annotations:  Associated to 1 GO processes click arrow to show/hide IEA associations GO:0042060 wound healing IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Alagille syndrome 2; ALGS2 Synonyms: Alagille syndrome [Disease Ontology: DOID:9245] Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629] Disease Ontology: DOID:9245 OMIM: 610205 Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955] Disease Ontology: DOID:2736 OMIM: 102500 Orphanet: ORPHA955