Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	2471	1p12	NOTCH2	notch receptor 2
Mouse	1	2473	3 42.42 cM	Notch2	notch 2
Rat	1	2471	2q34	Notch2	notch receptor 2

Previous and Unofficial Names

notch 2 | "Notch homolog 2 (Drosophila)

Database Links
Alphafold	Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
CATH/Gene3D	1.25.40.20
ChEMBL Target	CHEMBL3407320 (Hs)
Ensembl Gene	ENSG00000134250 (Hs), ENSMUSG00000027878 (Mm), ENSRNOG00000018835 (Rn)
Entrez Gene	4853 (Hs), 18129 (Mm), 29492 (Rn)
Human Protein Atlas	ENSG00000134250 (Hs)
KEGG Gene	hsa:4853 (Hs), mmu:18129 (Mm), rno:29492 (Rn)
OMIM	600275 (Hs)
Pharos	Q04721 (Hs)
RefSeq Nucleotide	NM_024408 (Hs), NM_010928 (Mm), NM_024358 (Rn)
RefSeq Protein	NP_077719 (Hs), NP_035058 (Mm), NP_077334 (Rn)
UniProtKB	Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
Wikipedia	NOTCH2 (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference Jagged2 {Sp: Human} Mm Activation - - 2 ⤷ [2] Description: Determined as binding to Notch2 on the surface of BaF3 cells

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference tarextumab Hs Binding >10.0 pKd 1 ⤷ pKd >10.0 (Kd <1x10-10 M) [1]

Immuno Process Associations

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002315 marginal zone B cell differentiation ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes, IEA only GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0043011 myeloid dendritic cell differentiation IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes, IEA only GO:2001204 regulation of osteoclast development IMP click arrow to show/hide IEA associations GO:0045672 positive regulation of osteoclast differentiation IEA

Immuno Process:  Tissue repair GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0042060 wound healing IEA

Immuno Process:  Immune system development GO Annotations:  Associated to 3 GO processes, IEA only GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0043011 myeloid dendritic cell differentiation IEA GO:0045672 positive regulation of osteoclast differentiation IEA

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes, IEA only GO:0002315 marginal zone B cell differentiation ISS click arrow to show/hide IEA associations GO:0002437 inflammatory response to antigenic stimulus IEA GO:0043011 myeloid dendritic cell differentiation IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Alagille syndrome 2; ALGS2 Synonyms: Alagille syndrome [Disease Ontology: DOID:9245] Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629] Disease Ontology: DOID:9245 OMIM: 610205 Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955] Disease Ontology: DOID:2736 OMIM: 102500 Orphanet: ORPHA955