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notch receptor 2

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Target not currently curated in GtoImmuPdb

Target id: 2859

Nomenclature: notch receptor 2

Family: Notch receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2471 1p12 NOTCH2 notch receptor 2
Mouse 1 2473 3 42.42 cM Notch2 notch 2
Rat 1 2471 2q34 Notch2 notch receptor 2
Previous and Unofficial Names Click here for help
notch 2 | "Notch homolog 2 (Drosophila)
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
tarextumab Peptide Primary target of this compound Click here for species-specific activity table Hs Binding >10.0 pKd 1
pKd >10.0 (Kd <1x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002315 marginal zone B cell differentiation ISS
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GO:0002437 inflammatory response to antigenic stimulus IEA
GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002315 marginal zone B cell differentiation ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 5 GO processes
GO:0002315 marginal zone B cell differentiation ISS
GO:0030097 hemopoiesis TAS
GO:2001204 regulation of osteoclast development IMP
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GO:0043011 myeloid dendritic cell differentiation IEA
GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:2001204 regulation of osteoclast development IMP
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GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0002315 marginal zone B cell differentiation ISS
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GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  Cytokine production & signalling
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0042246 tissue regeneration IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Alagille syndrome 2; ALGS2
Synonyms: Alagille syndrome [Disease Ontology: DOID:9245]
Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629]
Disease Ontology: DOID:9245
OMIM: 610205
Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS
Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955]
Disease Ontology: DOID:2736
OMIM: 102500
Orphanet: ORPHA955

References

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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

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