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notch receptor 2

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Target not currently curated in GtoImmuPdb

Target id: 2859

Nomenclature: notch receptor 2

Family: Notch receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2471 1p12 NOTCH2 notch receptor 2
Mouse 1 2473 3 42.42 cM Notch2 notch 2
Rat 1 2471 2q34 Notch2 notch receptor 2
Previous and Unofficial Names Click here for help
notch 2 | "Notch homolog 2 (Drosophila)
Database Links Click here for help
CATH/Gene3D 1.25.40.20
ChEMBL Target CHEMBL3407320 (Hs)
Ensembl Gene ENSG00000134250 (Hs), ENSMUSG00000027878 (Mm), ENSRNOG00000018835 (Rn)
Entrez Gene 4853 (Hs), 18129 (Mm), 29492 (Rn)
Human Protein Atlas ENSG00000134250 (Hs)
KEGG Gene hsa:4853 (Hs), mmu:18129 (Mm), rno:29492 (Rn)
OMIM 600275 (Hs)
Pharos Q04721 (Hs)
RefSeq Nucleotide NM_024408 (Hs), NM_010928 (Mm), NM_024358 (Rn)
RefSeq Protein NP_077719 (Hs), NP_035058 (Mm), NP_077334 (Rn)
UniProtKB Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
Wikipedia NOTCH2 (Hs)

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
tarextumab Peptide Primary target of this compound Click here for species-specific activity table Hs Binding >10.0 pKd 1
⤷ pKd >10.0 (Kd <1x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002315 marginal zone B cell differentiation ISS
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GO:0002437 inflammatory response to antigenic stimulus IEA
GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002315 marginal zone B cell differentiation ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 5 GO processes
GO:0002315 marginal zone B cell differentiation ISS
GO:0030097 hemopoiesis TAS
GO:2001204 regulation of osteoclast development IMP
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GO:0043011 myeloid dendritic cell differentiation IEA
GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:2001204 regulation of osteoclast development IMP
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GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0002315 marginal zone B cell differentiation ISS
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GO:0043011 myeloid dendritic cell differentiation IEA
Immuno Process:  Cytokine production & signalling
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0042246 tissue regeneration IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Alagille syndrome 2; ALGS2
Synonyms: Alagille syndrome [Disease Ontology: DOID:9245]
Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629]
Disease Ontology: DOID:9245
OMIM: 610205
Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS
Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955]
Disease Ontology: DOID:2736
OMIM: 102500
Orphanet: ORPHA955

References

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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

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