EF-hand domain containing proteins

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Targets
Other protein targets
EF-hand domain containing proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide More detailed introduction go icon to follow link

The EF hand is conserved structural domain that is found in a large family of calcium-binding proteins. It is formed by two alpha helices linked by a short loop region.

Targets

nucleobindin 1 Show summary »« Hide summary

RAS guanyl releasing protein 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3016
Nomenclature	RAS guanyl releasing protein 1
Previous and unofficial names	calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II \| CalDAG-GEFII \| RASGRP \| RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Genes	RASGRP1 (Hs), Rasgrp1 (Mm), Rasgrp1 (Rn)
Ensembl ID	ENSG00000172575 (Hs), ENSMUSG00000027347 (Mm), ENSRNOG00000005404 (Rn)
UniProtKB AC	O95267 (Hs), Q9Z1S3 (Mm), Q9R1K8 (Rn)

S100 calcium binding protein A11 / S100A11 Show summary »« Hide summary More detailed page go icon to follow link

References

Show »« Hide

How to cite this family page

Database page citation:

EF-hand domain containing proteins. Accessed on 16/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=915.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.