Immunoglobulin C1-set domain-containing proteins: Introduction

The C1-set domain is a classical Ig (antibody) constant domain-like region. It is predominantly found in proteins of the immune system., including proteins of the MHC class I and II complex, and a number of T cell receptors.
FcRn (FCGRT) is a C1-set domain-containing protein that is important for developing immunity in the neonate [1], and for regulating IgG levels in the mature immune system [2].


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1. Jones EA, Waldmann TA. (1972) The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest, 51 (11): 2916-27. [PMID:5080417]

2. Kuo TT, Aveson VG. (2011) Neonatal Fc receptor and IgG-based therapeutics. MAbs, 3 (5): 422-30. [PMID:22048693]

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Immunoglobulin C1-set domain-containing proteins, introduction. Last modified on 08/02/2018. Accessed on 15/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY,