LB-100 [Ligand Id: 11105] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297300 (Lb-100, LB 100) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein phosphatase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3425389] [UniProtKB: P53041] | ||||||||
| ChEMBL | Inhibition of human PP5 phosphatase domain extracted from Escherichia coli BL21 using pNPP as substrate incubated for 30 mins by spectrophotometric analysis | B | 4.66 | pIC50 | 22110 | nM | IC50 | J Med Chem (2024) 67: 15080-15097 [PMID:39145509] |
| ChEMBL | Inhibition of DDO-3733 preincubated human PP5 phosphatase domain extracted from Escherichia coli BL21 using pNPP as substrate incubated for 30 mins by spectrophotometric analysis | B | 4.68 | pIC50 | 21080 | nM | IC50 | J Med Chem (2024) 67: 15080-15097 [PMID:39145509] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
