ChEMBL ligand: CHEMBL1200438 (NSC-759169, Tioconazol, Tioconazole, Trosyl, Tz-3, UK-20,349, UK-20349, Vagistat-1)
Cysteine protease ATG4A in Human [ChEMBL: CHEMBL5169181] [UniProtKB: Q8WYN0] There should be some charts here, you may need to enable JavaScript!
autophagy related 4B cysteine peptidase/Cysteine protease ATG4B in Human [ChEMBL: CHEMBL1741221] [GtoPdb: 2329] [UniProtKB: Q9Y4P1] There should be some charts here, you may need to enable JavaScript!
CYP17A1/Cytochrome P450 17A1 in Human [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
CYP8B1 in Human [GtoPdb: 1357] [UniProtKB: Q9UNU6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cysteine protease ATG4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5169181] [UniProtKB: Q8WYN0]
ChEMBL	Inhibition of ATG4A (unknown origin)	B	5.89	pIC50	1300	nM	IC50	Eur J Med Chem (2021) 209: 112917-112917 [PMID:33077263]
autophagy related 4B cysteine peptidase/Cysteine protease ATG4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741221] [GtoPdb: 2329] [UniProtKB: Q9Y4P1]
ChEMBL	Inhibition of ATG4B (unknown origin)	B	5.74	pIC50	1800	nM	IC50	Eur J Med Chem (2021) 209: 112917-112917 [PMID:33077263]
CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093]
ChEMBL	In vitro inhibition of human Cytochrome P450 17A1 activity	B	6.3	pKi	505	nM	Ki	J Med Chem (2003) 46: 2345-2351 [PMID:12773039]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.97	pIC50	1070	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	6.2	pIC50	630	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
CYP8B1 in Human [GtoPdb: 1357] [UniProtKB: Q9UNU6]
GtoPdb	-	-	6.68	pKd	210	nM	Kd	J Biol Chem (2022) 298: 102344 [PMID:35944583]
GtoPdb	Inhibition of catalytic activity	-	5.4	pIC50	3940	nM	IC50	J Biol Chem (2022) 298: 102344 [PMID:35944583]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]