NVP-BHG712 [Ligand Id: 14226] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL3752910 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA1 | B | 6.52 | pIC50 | 303.4 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
| GtoPdb | - | - | 7.89 | pKd | 13 | nM | Kd | ChemMedChem (2018) 13: 1629-1633 [PMID:29928781] |
| ChEMBL | Affinity Biochemical interaction (Microscale thermophoresis (MST) assay) EUB0000143b EPHA2 | B | 7.89 | pIC50 | 13 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3 |
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA2 | B | 8.48 | pIC50 | 3.3 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| ChEMBL | Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA2 | B | 8.52 | pIC50 | 3 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA3 | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA4 | B | 8.12 | pIC50 | 7.6 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA5 | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA6 | B | 6.58 | pIC50 | 263 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA7 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHA8 | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHB2 | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHB3 | B | 8.22 | pIC50 | 6 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
| GtoPdb | - | - | 8.22 | pKd | 6 | nM | Kd | ChemMedChem (2018) 13: 1629-1633 [PMID:29928781] |
| ChEMBL | Affinity Biochemical interaction (Microscale thermophoresis (MST) assay) EUB0000143b EPHB4 | B | 8.22 | pIC50 | 6 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3 |
| ChEMBL | Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHB4 | B | 8.52 | pIC50 | 3 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomics Library wave 3 |
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHB4 | B | 8.52 | pIC50 | 3 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197] | ||||||||
| ChEMBL | Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000143b EPHB6 | B | 5.35 | pIC50 | 4477.1 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Selectivity interaction (Kinase panel (TR-FRET-based LanthaScreen™ and Caliper mobility shift assays)) EUB0000143b RAF1 | B | 6.4 | pIC50 | 395 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Selectivity interaction (Kinase panel (TR-FRET-based LanthaScreen™ and Caliper mobility shift assays)) EUB0000143b ABL1 | B | 5.78 | pIC50 | 1667 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Selectivity interaction (Kinase panel (TR-FRET-based LanthaScreen™ and Caliper mobility shift assays)) EUB0000143b SRC | B | 5.9 | pIC50 | 1266 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of VEGFR2 (unknown origin) autophosphorylation after 2 hrs by cell-based assay | B | 5.38 | pEC50 | 4200 | nM | EC50 | Medchemcomm (2015) 6: 1518-1534 |
| TBC1 domain family member 15 in Human [GtoPdb: 3328] [UniProtKB: Q8TC07] | ||||||||
| GtoPdb | Binding affinity determined in a Kinobeads assay | - | 6.2 | pKd | 624 | nM | Kd | ChemMedChem (2018) 13: 1629-1633 [PMID:29928781] |
| SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 in Human [GtoPdb: 3330] [UniProtKB: Q9Y3Z3] | ||||||||
| GtoPdb | - | - | 8.44 | pKd | 3.6 | nM | Kd | ChemMedChem (2018) 13: 1629-1633 [PMID:29928781] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
