ChEMBL ligand: CHEMBL244403
CB1 receptor/Cannabinoid receptor 1 in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB1 receptor/Cannabinoid receptor 1 in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid receptor 2 in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CB1 receptor/Cannabinoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells	B	7.46	pKi	35	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1619-1624 [PMID:22284817]
ChEMBL	Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells	B	7.46	pKi	35	nM	Ki	Bioorg Med Chem Lett (2012) 22: 3884-3889 [PMID:22607668]
GtoPdb	-	-	7.46	pKi	35	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1619-24 [PMID:22284817]
ChEMBL	Displacement of [3H]SR141716A from membrane bound human CB1 receptor after 1 hr by beta scintillation counting method	B	5.8	pIC50	1580	nM	IC50	Bioorg Med Chem (2018) 26: 5069-5078 [PMID:30217464]
ChEMBL	Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cells	B	7.82	pIC50	15	nM	IC50	J Med Chem (2007) 50: 3851-3856 [PMID:17630726]
ChEMBL	Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as [35S]GTPgamma binding	F	7.14	pEC50	73	nM	EC50	Bioorg Med Chem Lett (2012) 22: 3884-3889 [PMID:22607668]
ChEMBL	Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay	F	7.14	pEC50	72	nM	EC50	Bioorg Med Chem Lett (2012) 22: 1619-1624 [PMID:22284817]
ChEMBL	Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as reversal of forskolin-evoked cAMP accumulation	F	8.21	pEC50	6.1	nM	EC50	J Med Chem (2007) 50: 3851-3856 [PMID:17630726]
CB1 receptor/Cannabinoid receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL	Inhibition of rat CB1 receptor	B	7.66	pIC50	22	nM	IC50	J Med Chem (2007) 50: 3851-3856 [PMID:17630726]
CB2 receptor/Cannabinoid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
GtoPdb	-	-	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1619-24 [PMID:22284817]
ChEMBL	Binding affinity to human CB2 receptor	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1619-1624 [PMID:22284817]
ChEMBL	Binding affinity to human CB2 receptor	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2012) 22: 3884-3889 [PMID:22607668]
ChEMBL	Displacement of [3H]CP55940 from membrane bound human CB2 receptor after 1 hr by beta scintillation counting method	B	5.28	pIC50	5300	nM	IC50	Bioorg Med Chem (2018) 26: 5069-5078 [PMID:30217464]
ChEMBL	Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cells	B	7.01	pIC50	98	nM	IC50	J Med Chem (2007) 50: 3851-3856 [PMID:17630726]
ChEMBL	Agonist activity at human CB2 receptor expressed in CHOK1 cells assessed as reversal of forskolin-evoked cAMP accumulation	F	7.55	pEC50	27.9	nM	EC50	J Med Chem (2007) 50: 3851-3856 [PMID:17630726]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]