ChEMBL ligand: CHEMBL4297641 (Sp-2577, SP-2577, Seclidemstat, SP2577)
lysine demethylase 1A/Lysine-specific histone demethylase 1A in Human [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine demethylase 1A/Lysine-specific histone demethylase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341]
ChEMBL	Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assay	B	7.51	pKi	31	nM	Ki	J Med Chem (2023) 66: 71-94 [PMID:36537915]
GtoPdb	-	-	7.51	pKi	31	nM	Ki	J Med Chem (2023) 66: 71-94 [PMID:36537915]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	6.9	pIC50	127	nM	IC50	J Med Chem (2023) 66: 4275-4293 [PMID:37014989]
ChEMBL	Inhibition of human recombinant LSD1 expressed in Escherichia coli using H3K4me2 peptide as substrate incubated for 60 mins by AlphaLISA assay	B	7.58	pIC50	26.2	nM	IC50	ACS Med Chem Lett (2023) 14: 1389-1395 [PMID:37849536]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	7.89	pIC50	13	nM	IC50	J Med Chem (2023) 66: 71-94 [PMID:36537915]
ChEMBL	Inhibition of LSD1 (unknown origin)	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2022) 240: 114564-114564 [PMID:35820351]
ChEMBL	Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 1 hr by fluorescence based analysis	B	7.89	pIC50	13	nM	IC50	J Med Chem (2024) 67: 922-951 [PMID:38214982]
ChEMBL	Inhibition of human recombinant LSD1 expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence based analysis	B	7.89	pIC50	13	nM	IC50	J Med Chem (2024) 67: 922-951 [PMID:38214982]
ChEMBL	Inhibition of human LSD1	B	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2024) 114: 129982-129982 [PMID:39384076]
GtoPdb	Inhibition of LSD1 enzymatic activity in a biochemical assay	-	7.89	pIC50	13	nM	IC50	PLoS One (2020) 15: e0235705 [PMID:32649682]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]