Synonyms: FCE-22101 | FCE22101
Compound class:
Synthetic organic
Comment: Ritipenem (FCE 22101) is a penem antibacterial compound belonging to the β-lactam group and exhibits broad-spectrum bacteriolytic activity [3-4]. Its activity profile is similar to that of imipenem, but it shows no activity against Pseudomonas aeruginosa. It is delivered as the orally bioavailable prodrug ritipenem acoxyl (Penemac®, FCE-22891).
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References |
1. Afonso A, Hon F, Weinstein J, Gentles M, Shapiro E, Ganguly A, Naples L, Hare R, Miller G. (1993)
Penems containing amino acid derived substituents at C-2. Bioorg Med Chem Lett, 3: 2177-2182. DOI: 10.1016/S0960-894X(01)80921-5 |
2. Altamura M, Perrotta E, Sbraci P, Pestellini V, Arcamone F, Cascio G, Lorenzi L, Satta G, Morandotti G, Sperning R. (1995)
2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. J Med Chem, 38 (21): 4244-56. [PMID:7473551] |
3. Inui T, Oshida T, Endo T, Matsushita T. (1999)
Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae. Antimicrob Agents Chemother, 43 (10): 2534-7. [PMID:10508039] |
4. Poggesi I, Spinelli R, Frigerio E, Strolin Benedetti M, Carra L, Sassella D, Rimoldi R. (1997)
A study of the pharmacokinetics and tolerability of ritipenem acoxil in healthy volunteers following multiple oral dosing. J Antimicrob Chemother, 40 (2): 291-4. [PMID:9301999] |