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trospectomycin   Click here for help

GtoPdb Ligand ID: 10870

Synonyms: U-63,366F | U-63366F | U63366F
Compound class: Synthetic organic
Comment: Trospectomycin is an aminocyclitol. It inhibits the protein synthesis function of the bacterial 30S ribosomal subunit [3-4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 5
Rotatable bonds 5
Topological polar surface area 129.51
Molecular weight 374.21
XLogP -0.42
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCCC[C@H]1O[C@H]2O[C@@H]3[C@@H](O)[C@H](NC)[C@@H]([C@@H]([C@H]3O[C@]2(C(=O)C1)O)NC)O
Isomeric SMILES CCCC[C@H]1O[C@H]2O[C@@H]3[C@@H](O)[C@H](NC)[C@@H]([C@@H]([C@H]3O[C@]2(C(=O)C1)O)NC)O
InChI InChI=1S/C17H30N2O7/c1-4-5-6-8-7-9(20)17(23)16(24-8)25-15-13(22)10(18-2)12(21)11(19-3)14(15)26-17/h8,10-16,18-19,21-23H,4-7H2,1-3H3/t8-,10-,11+,12+,13+,14-,15-,16+,17+/m1/s1
InChI Key KHAUBYTYGDOYRU-IRXASZMISA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Chatwani A, Dandalou V, Harmanli O, Nyirjesy P. (1997)
Trospectomycin in acute pelvic inflammatory disease: a preliminary report.
Infect Dis Obstet Gynecol, 5 (3): 215-8. [PMID:18476139]
2. Chatwani A, Martens M, Blanco J, Gall S, Przybylko K, Wajszczuk CP, Nickens D. (1997)
Double-blind, multicenter, prospective randomized study of trospectomycin vs. Clindamycin, both with aztreonam, in non-community acquired obstetric and gynecologic infections.
Infect Dis Obstet Gynecol, 5 (4): 280-5. [PMID:18476152]
3. Yancey Jr RJ, Klein LK. (1988)
In-vitro activity of trospectomycin sulphate against Mycoplasma and Ureaplasma species isolated from humans.
J Antimicrob Chemother, 21 (6): 731-6. [PMID:2970452]
4. Zurenko GE, Yagi BH, Vavra JJ, Wentworth BB. (1988)
In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.
Antimicrob Agents Chemother, 32 (2): 216-23. [PMID:2966608]