Synonyms: CRS-3123 | REP-3123 | REP3123
Compound class:
Synthetic organic
Comment: CRS3123 is an orally bioactive, diaryldiamine compound that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria [1]. It has limited antibacterial activity against normal anaerobic gut flora (e.g. Clostridium ramosum, bifidobacteria, lactobacilli of the Lactobacillus casei-rhamnosus-plantarum group) and Gram-negative anaerobes.
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Bioactivity Comments |
CRS3123 was effective against all isolates of C. difficile (MIC 0.5-1 μg/ml) in vitro, including those with resistance to moxifloxacin and clindamycin [1]. |