Synonyms: compound 4 [PMID: 19736016] | DX619
Compound class:
Synthetic organic
Comment: DX-619 is a des-fluoroquinolone antibacterial [2-3].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Credito K, Lin G, Appelbaum PC. (2007)
Antistaphylococcal activity of DX-619 alone and in combination with vancomycin, teicoplanin, and linezolid assessed by time-kill synergy testing. Antimicrob Agents Chemother, 51 (4): 1508-11. [PMID:17261625] |
2. Fujikawa K, Chiba M, Tanaka M, Sato K. (2005)
In vitro antibacterial activity of DX-619, a novel des-fluoro(6) quinolone. Antimicrob Agents Chemother, 49 (7): 3040-5. [PMID:15980395] |
3. Miyauchi R, Kawakami K, Ito M, Matsuhashi N, Ohki H, Inagaki H, Takahashi H, Takemura M. (2009)
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorg Med Chem, 17 (19): 6879-89. [PMID:19736016] |