Synonyms: lidocaine N-oxide
Compound class:
Synthetic organic
Comment: OCT2013 is an aliphatic amine N-oxide that is converted to lidocaine in vivo [1]. This conversion can occur in the reducing environment of the ischaemic myocardium, an effect that may offer an alternative to lidocaine to produce conduction block during ventricular tachyarrhythmias.
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Bioactivity Comments |
OCT2013 prevents ischaemia-induced ventricular fibrillation in isolated rat hearts without causing the adverse effects observed with lidocaine, and provides an antiarrhythmic action in ischaemia-induced arrhythmias in rats in vivo. |