Synonyms: compound 5a [PMID: 14980665] | loxoprofen trans-alcohol
Compound class:
Synthetic organic
Comment: HR1405-01 is a tromethamine salt of the active loxoprofenol (an NSAID) metabolite, loxoprofenol-SRS [1-2]. It was developed for potential anti-inflammatory and analgesic activities, and is formulated for intravenous administration.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Riendeau D, Salem M, Styhler A, Ouellet M, Mancini JA, Li CS. (2004)
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett, 14 (5): 1201-3. [PMID:14980665] |
2. Ye H, Lv T, Min T, Mao D, Chen X, Ding B, Zhang C. (2022)
HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials. Eur J Med Chem, 235: 114258. [PMID:35339101] |