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cephalosporin P1   Click here for help

GtoPdb Ligand ID: 12330

Synonyms: acremonic acid
Compound class: Natural product
Comment: Cephalosporin P1 is the main active component in cephalosporin P, a fungal metabolite isolated from the culture broth of Acremonium chrysogenum (formerly known as Cephalosporium) [1]. It is a fusidane antibacterial compound.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 130.36
Molecular weight 574.35
XLogP 5.4
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(=O)O[C@H]1C[C@]2([C@H](/C/1=C(/C(=O)O)\CCC=C(C)C)CC[C@@H]1[C@]2(C)[C@@H](O)[C@H](OC(=O)C)[C@@H]2[C@]1(C)CC[C@H]([C@H]2C)O)C
Isomeric SMILES C[C@@H]1[C@@H](CC[C@]2([C@H]1[C@H]([C@@H]([C@]1([C@H]2CC[C@@H]2[C@@]1(C[C@@H](/C/2=C(/CCC=C(C)C)\C(=O)O)OC(=O)C)C)C)O)OC(=O)C)C)O
InChI InChI=1S/C33H50O8/c1-17(2)10-9-11-21(30(38)39)26-22-12-13-25-31(6)15-14-23(36)18(3)27(31)28(41-20(5)35)29(37)33(25,8)32(22,7)16-24(26)40-19(4)34/h10,18,22-25,27-29,36-37H,9,11-16H2,1-8H3,(H,38,39)/b26-21-/t18-,22+,23-,24+,25+,27-,28-,29+,31-,32+,33-/m1/s1
InChI Key YJJWILCYIMMPAS-VALXSNPUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Natural product
IUPAC Name Click here for help
(2Z)-2-[(3R,4S,5S,6R,7R,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-3,7-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
Synonyms Click here for help
acremonic acid
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cephalosporin P1
Other databases
CAS Registry No. 13258-72-5 (source: Scifinder)
ChEMBL Ligand CHEMBL3401949
GtoPdb PubChem SID 479821121
PubChem CID 3037114
Search Google for chemical match using the InChIKey YJJWILCYIMMPAS-VALXSNPUSA-N
Search Google for chemicals with the same backbone YJJWILCYIMMPAS
UniChem Compound Search for chemical match using the InChIKey YJJWILCYIMMPAS-VALXSNPUSA-N
UniChem Connectivity Search for chemical match using the InChIKey YJJWILCYIMMPAS-VALXSNPUSA-N