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pristinamycin IIA   Click here for help

GtoPdb Ligand ID: 12933

Synonyms: mikamycin A | ostreogrycin A | Pyostacine® | streptogramin A | virginiamycin M1
Approved drug PDB Ligand
pristinamycin IIA is an approved drug (France, 1995)
Compound class: Natural product
Comment: Pristinamycin IIA is a macrolide that is, together with pristinamycin IA, a component of pristinamycin (PubChem CID 11979535), a streptogramin antibacterial produced by Streptomyces pristinaespiralis [1]. Note that the INN describes the mixture.

pristinamycin IIA is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 134.6
Molecular weight 525.59
XLogP 1.38
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C)[C@@H]1[C@H](C)/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)O1)O)/C
Isomeric SMILES C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)O[C@@H]1C(C)C)O)/C
InChI InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1
InChI Key DAIKHDNSXMZDCU-FQTGFAPKSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Natural product
Approved drug? Yes. France (1995)
IUPAC Name Click here for help
(10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone
International Nonproprietary Names Click here for help
INN number INN
1258 pristinamycin
Synonyms Click here for help
mikamycin A | ostreogrycin A | Pyostacine® | streptogramin A | virginiamycin M1
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Pristinamycin
Other databases
CAS Registry No. 21411-53-0 (source: Scifinder)
ChEBI CHEBI:9997
ChEMBL Ligand CHEMBL1236670
DrugBank Ligand DB01669
GtoPdb PubChem SID 485206054
PubChem CID 5459319
RCSB PDB Ligand VIR
Search Google for chemical match using the InChIKey DAIKHDNSXMZDCU-FQTGFAPKSA-N
Search Google for chemicals with the same backbone DAIKHDNSXMZDCU
Search PubMed clinical trials pristinamycin
Search PubMed titles pristinamycin
Search PubMed titles/abstracts pristinamycin
UniChem Compound Search for chemical match using the InChIKey DAIKHDNSXMZDCU-FQTGFAPKSA-N
UniChem Connectivity Search for chemical match using the InChIKey DAIKHDNSXMZDCU-FQTGFAPKSA-N
Wikipedia Pristinamycin IIA

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MedChemExpress
Virginiamycin M1 (links to external site)
Cat. No. HY-N6686
(Same CID)