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myricetin   Click here for help

GtoPdb Ligand ID: 13074

Synonyms: 3,3',4',5,5',7-hexahydroxyflavone | cannabiscetin
PDB Ligand
Compound class: Natural product
Comment: Myricetin is a plant-derived natural product. It is a flavonoid with a range of pharmacological activities that suggest potential therapeutic opportunities in diabetes, liver disease and cancer [2-3,5-7].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 6
Rotatable bonds 1
Topological polar surface area 147.68
Molecular weight 318.24
XLogP 1.91
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=C(C(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O)O)O2)O)O)O)O
Isomeric SMILES C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI Key IKMDFBPHZNJCSN-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011)
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
Bioorg Med Chem, 19 (9): 2842-9. [PMID:21482471]
2. Babotă M, Frumuzachi O, Tanase C, Mocan A. (2024)
Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies.
Nutrients, 16 (21). [PMID:39519561]
3. Chen M, Zhang S, Huang X, Zhang D, Zhu D, Ouyang C, Li Y. (2025)
The protective effects and mechanism of myricetin in liver diseases (Review).
Mol Med Rep, 31 (4). [PMID:39917997]
4. Hagiwara M, Inoue S, Tanaka T, Nunoki K, Ito M, Hidaka H. (1988)
Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.
Biochem Pharmacol, 37 (15): 2987-92. [PMID:3164998]
5. Oldoni TLC, da Silva C, Bicas TC, Ayres BRB, Zanchet ER, Marafon F, da Silva AP, Carpes ST, Bagatini MD, Ascari J et al.. (2025)
Antihyperglycemic activity and bioguided isolation of phenolic compounds with antioxidant and cytotoxic properties from Syzygium malaccense leaves.
Fitoterapia, 181: 106357. [PMID:39732206]
6. Pattanaik SK, Anil MP, Jena S, Rath D. (2024)
A Mechanism-based Perspective on the Use of Flavonoids in the Treatment of Diabetes and its Complications.
Curr Diabetes Rev, [Epub ahead of print]. [PMID:39620338]
7. Phosrithong N, Ungwitayatorn J. (2010)
Molecular docking study on anticancer activity of plant-derived natural products.
Med Chem Res, 19: 817–835. DOI: 10.1007/s00044-009-9233-5
8. Williams LK, Li C, Withers SG, Brayer GD. (2012)
Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J Med Chem, 55 (22): 10177-86. [PMID:23050660]